OTS186935

Names

[ CAS No. ]:
2093400-18-9

[ Name ]:
OTS186935

Biological Activity

[Description]:

OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

IC50: 6.49 nM (SUV39H2)[1]

[In Vitro]

OTS186935 inhibits A549 cell growth with IC50 of 0.67 μM[1].

[In Vivo]

OTS186935 reveales significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity[1].

[References]

[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₆ClN₅O₂

[ Molecular Weight ]:
463.96

OTS186935

Names

Biological Activity

Chemical & Physical Properties

Related Compounds