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Chmfl-btk-01

Names

[ CAS No. ]:
2095280-64-9

[ Name ]:
Chmfl-btk-01

Biological Activity

[Description]:

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[Target]

IC50: 7 nM (BTK)[1].


[References]

[1]. Liang Q, et al. Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem. 2017 May 5;131:107-125.

Chemical & Physical Properties

[ Molecular Formula ]:
C38H41N5O5

[ Molecular Weight ]:
647.76

Related Compounds