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MELK inhibitor 17

Names

[ CAS No. ]:
2095596-44-2

[ Name ]:
MELK inhibitor 17

Biological Activity

[Description]:

MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> MELK

[Target]

IC50: 3 nM (MELK) Ki: 0.39 nM (MELK)[1]


[References]

[1]. Edupuganti R, et al. Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem. 2017 May 1;25(9):2609-2616.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H33N5O4

[ Molecular Weight ]:
539.62

Related Compounds