Thalidomide-NH-PEG2-C2-NH2 TFA

Names

[ CAS No. ]:
2097509-36-7

[ Name ]:
Thalidomide-NH-PEG2-C2-NH2 TFA

Biological Activity

[Description]:

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[References]

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₅F₃N₄O₈

[ Molecular Weight ]:
518.44

Safety Information

[ Hazard Codes ]:
Xi

Thalidomide-NH-PEG2-C2-NH2 TFA

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds