MM-589

Names

[ CAS No. ]:
2097887-20-0

[ Name ]:
MM-589

Biological Activity

[Description]:

MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]

[In Vitro]

MM-589 (0.01-10 µM) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].

[In Vivo]

MM-589 has excellent microsomal stability in human, mouse, and rat microsomes[1].

[References]

[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₄₄N₈O₅

[ Molecular Weight ]:
572.70

MM-589

Names

Biological Activity

Chemical & Physical Properties

Related Compounds