KRpep-2d

Names

[ CAS No. ]:
2098181-84-9

[ Name ]:
KRpep-2d

Biological Activity

[Description]:

KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

K-RAS

[In Vitro]

KRpep-2d has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1]. KRpep-2d (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1].

[References]

[1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀₉H₁₈₃N₄₃O₂₅S₂

[ Molecular Weight ]:
2560.02

KRpep-2d

Names

Biological Activity

Chemical & Physical Properties

Related Compounds