Propargyl-PEG5-CH2CO2tBu

Names

[ CAS No. ]:
2098489-63-3

[ Name ]:
Propargyl-PEG5-CH2CO2tBu

Biological Activity

[Description]:

Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₃₀O₇

[ Molecular Weight ]:
346.42

[ Storage condition ]:
2-8°C

Propargyl-PEG5-CH2CO2tBu

Names

Biological Activity

Chemical & Physical Properties

Related Compounds