Thalidomide-PEG4-Propargyl

Names

[ CAS No. ]:
2098799-77-8

[ Name ]:
Thalidomide-PEG4-Propargyl

Biological Activity

[Description]:

Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-998.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₈N₂O₉

[ Molecular Weight ]:
488.49

Safety Information

[ Hazard Codes ]:
Xi

Thalidomide-PEG4-Propargyl

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds