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N-(Amino-PEG1)-N-bis(PEG2-propargyl)

Names

[ CAS No. ]:
2100306-47-4

[ Name ]:
N-(Amino-PEG1)-N-bis(PEG2-propargyl)

[Synonym ]:
6-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl}-3,9,12-trioxa-6-azapentadec-14-yn-1-amine
MFCD30723225
3,9,12-Trioxa-6-azapentadec-14-yn-1-amine, 6-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-

Biological Activity

[Description]:

N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
443.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H32N2O5

[ Molecular Weight ]:
356.457

[ Flash Point ]:
222.2±27.3 °C

[ Exact Mass ]:
356.231110

[ LogP ]:
-2.60

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.490

Related Compounds