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(rel)-ML-SI3

Names

[ CAS No. ]:
2108567-79-7

[ Name ]:
(rel)-ML-SI3

[Synonym ]:
MFCD32690912

Biological Activity

[Description]:

(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy

[Target]

IC50: 4.7 μM (TRPML1), 1.7 μM (TRPML2)[1]


[References]

[1].  

[2].  

Chemical & Physical Properties

[ Density]:
1.26±0.1 g/cm3(Predicted)

[ Boiling Point ]:
589.3±60.0 °C(Predicted)

[ Molecular Formula ]:
C23H31N3O3S

[ Molecular Weight ]:
429.58


Related Compounds