(rel)-ML-SI3
Names
Biological Activity
[Description]:
(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][2].
[Related Catalog]:
[Target]
IC50: 4.7 μM (TRPML1), 1.7 μM (TRPML2)[1]
[References]
[1].
[2].
Chemical & Physical Properties
[ Density]:
1.26±0.1 g/cm3(Predicted)
[ Boiling Point ]:
589.3±60.0 °C(Predicted)
[ Molecular Formula ]:
C23H31N3O3S
[ Molecular Weight ]:
429.58