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STAT5-IN-2

Names

[ CAS No. ]:
2111834-61-6

[ Name ]:
STAT5-IN-2

Biological Activity

[Description]:

STAT5-IN-2 is a STAT5 inhibitor with EC50s of 9 μM and 5 μM in K562 and KU812 cells, respectively. Potent antileukemic effect[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

EC50: 9 μM (K562 cells), 5 μM (KU812 cells)[1]


[References]

[1]. Juen L, et al. New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias. J Med Chem. 2017 Jul 27;60(14):6119-6136.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H27N3O

[ Molecular Weight ]:
397.51

Related Compounds