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Oleanolic acid derivative 2

Names

[ CAS No. ]:
211516-63-1

[ Name ]:
Oleanolic acid derivative 2

[Synonym ]:
7aH-Cyclopenta[a]chrysene-7a-carboxylic acid, 1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-5a,5b,10,10,13b-pentamethyl-3-oxo-, methyl ester, (3aR,5aR,5bS,7aS,11aS,13aR,13bR)-
Methyl (3aR,5aR,5bS,7aS,11aS,13aR,13bR)-5a,5b,10,10,13b-pentamethyl-3-oxo-1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-7aH-cyclopenta[a]chrysene-7a-carboxylate

Biological Activity

[Description]:

Oleanolic acid derivative 2 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Oleanolic acid suppress transcription or translation of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) genes. HY-18003 is extracted from the reference, compound 12a. For the transformation of olefin 9a (HY-18002) into ketone 12a (HY-18003), the obvious ozonolysis cannot be used because ozone also reacts with the C-12 olefin of oleanane triterpenoids to give the 12R,13R-epoxide, 12-ketone,9 and 12R-hydroxy lactone.[1].

[References]

[1]. Tadashi Honda, et al. Design and Synthesis of 23,24-Dinoroleanolic Acid Derivatives, Novel Triterpenoid-Steroid Hybrid Molecules. J. Org. Chem., 1998, 63 (14), pp 4846-4849.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
498.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H42O3

[ Molecular Weight ]:
426.631

[ Flash Point ]:
210.2±28.8 °C

[ Exact Mass ]:
426.313385

[ LogP ]:
7.38

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.544

[ Storage condition ]:
2-8℃

Related Compounds