(S,S,S)-AHPC hydrochloride

Names

[ Name ]:
(S,S,S)-AHPC hydrochloride

Biological Activity

[Description]:

(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

VHL

[In Vitro]

The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

[References]

[1]. Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61(2):583-598.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₁ClN₄O₃S

[ Molecular Weight ]:
467.02

[ Storage condition ]:
-20°C

(S,S,S)-AHPC hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds