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BIRT 377

Names

[ CAS No. ]:
213211-10-0

[ Name ]:
BIRT 377

[Synonym ]:
(5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-, (5R)-
(5R)-5-(4-Bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
(5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione

Biological Activity

[Description]:

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a Ki of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cytoskeleton >> Integrin

[Target]

Ki: 25.8 nM (LFA-1)[1]


[References]

[1]. Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163(10):5173-5177.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
518.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H15BrCl2N2O2

[ Molecular Weight ]:
442.13

[ Flash Point ]:
267.6±32.9 °C

[ Exact Mass ]:
439.969391

[ LogP ]:
4.76

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.632

Related Compounds