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Thalidomide-NH-PEG1-C2-NH2

Names

[ CAS No. ]:
2138439-12-8

[ Name ]:
Thalidomide-NH-PEG1-C2-NH2

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Biological Activity

[Description]:

Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
660.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H20N4O5

[ Molecular Weight ]:
360.365

[ Flash Point ]:
353.3±31.5 °C

[ Exact Mass ]:
360.143372

[ LogP ]:
-1.06

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.647

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds