Pyrroline-5-carboxylate

Names

[ Name ]:
Pyrroline-5-carboxylate

[Synonym ]:
d1-Pyrroline 2-carboxylate
3,4-DIHYDRO-2H-PYRROLIUM-5-CARBOXYLATE
4,5-dihydro-3H-pyrrole-2-carboxylic acid
delta1-Pyrroline 2-carboxylate
1-Pyrroline-2-carboxylic acid
4,5-Dihydro-3H-pyrrol-2-carbonsaeure
3,4-dihydro-2H-pyrrole-5-carboxylic acid
1-Pyrrolin-2-carbonsaeure
1-Pyrroline-2-carboxylate

Biological Activity

[Description]:

Pyrroline-5-carboxylate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
255.5ºC at 760mmHg

[ Molecular Formula ]:
C₅H₇NO₂

[ Molecular Weight ]:
113.11500

[ Flash Point ]:
108.3ºC

[ Exact Mass ]:
113.04800

[ PSA ]:
49.66000

[ Vapour Pressure ]:
0.00498mmHg at 25°C

[ Index of Refraction ]:
1.58

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%