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2′-O-methylcytidine

Names

[ CAS No. ]:
2140-72-9

[ Name ]:
2′-O-methylcytidine

[Synonym ]:
2'-OMe Cytidine
4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one
2'-OMeCytidine
2'-O-Methyl-D-cytidine
2’-O-Methyl Cytidine
O2'-methylcytidine
4-Amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydro-2-furanyl]-2(1H)-pyrimidinone
4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one
4-Amino-1-(2-O-methyl-β-D-ribofuranosyl)pyrimidin-2(1H)-on
Cytidine, 2'-O-methyl-
2'-OMe-C
2'-O-methyl-2'-deoxy-cytidine
2′-O-methylcytidine
MFCD00056067
2'-O-Methylcytidine
2&#39-O-Methylcytidine
2'-O-methyl-cytidine
4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one
2'-O-(TERT-BUTYLDIMETHYLSILYL)-6A-HYDROXY-7-EPI-PACLITAXEL

Biological Activity

[Description]:

2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[References]

[1]. Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
506.0±60.0 °C at 760 mmHg

[ Melting Point ]:
252-253ºC

[ Molecular Formula ]:
C10H15N3O5

[ Molecular Weight ]:
257.243

[ Flash Point ]:
259.8±32.9 °C

[ Exact Mass ]:
257.101166

[ PSA ]:
119.83000

[ LogP ]:
-1.09

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.677

[ Storage condition ]:
−20°C

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Precursor & DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds