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Thalidomide-NH-C2-PEG3-OH

Names

[ CAS No. ]:
2140807-23-2

[ Name ]:
Thalidomide-NH-C2-PEG3-OH

Biological Activity

[Description]:

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[In Vitro]

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

[References]

[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H27N3O8

[ Molecular Weight ]:
449.45

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds