H-Gly-Phe-βNA

Names

[ Name ]:
H-Gly-Phe-βNA

[Synonym ]:
GLY-PHE β-NAPHTHYLAMIDE

Biological Activity

[Description]:

Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Baumgartner HK, et, al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G296-307.

Chemical & Physical Properties

[ Density]:
1.254g/cm3

[ Boiling Point ]:
692.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₁N₃O₂

[ Molecular Weight ]:
347.41000

[ Flash Point ]:
372.6ºC

[ Exact Mass ]:
347.16300

[ PSA ]:
84.22000

[ LogP ]:
3.62870

[ Vapour Pressure ]:
5.04E-19mmHg at 25°C

[ Index of Refraction ]:
1.673

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Effect of glycyl-L-phenylalanine 2-naphthylamide on invertase endocytosed by rat liver.

Biochem. J. 225(3) , 645-8, (1985)

The release by glycyl-L-phenylalanine 2-naphthylamide (Gly-L-Phe-2-NNap) of endocytosed invertase associated with the MLP fraction (sum of the M, L and P fractions [de Duve, Pressman, Gianetto, Wattia...

Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes.

J. Cell Sci. 125(Pt 19) , 4567-75, (2012)

Elucidating mechanisms by which Ca(2+) signals are generated by monocytes is important for understanding monocyte function in health and disease. We have investigated mechanisms underlying Ca(2+) sign...

Calcium mobilization by nicotinic acid adenine dinucleotide phosphate (NAADP) in rat astrocytes.

Cell Calcium 39(2) , 143-53, (2006)

Nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown to release intracellular Ca(2+) in several types of cells. We have used Ca(2+)-sensitive fluorescent dyes (Fura-2, Fluo-4) to measu...