Angiogenesis inhibitor 2

Names

[ CAS No. ]:
2151067-32-0

[ Name ]:
Angiogenesis inhibitor 2

Biological Activity

[Description]:

Angiogenesis inhibitor 2 (compound 72) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 2 inhibits the proliferation of HUVEC and HCT-15 cells, with IC50 values of 1.93 and 0.21 μM. Angiogenesis inhibitor 2 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 2 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 2 inhibits the angiogenesis in zebrafish embryos[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Zhang RH, et al. Discovery of tetrandrine derivatives as tumor migration, invasion and angiogenesis inhibitors. Bioorg Chem. 2020 Aug;101:104025.

Chemical & Physical Properties

[ Molecular Formula ]:
C42H50N4O6S

[ Molecular Weight ]:
738.93

Related Compounds