BMS 753

Names

[ Name ]:
BMS 753

[Synonym ]:
Pentanoic acid,5-[[bis(diethoxyphosphinyl)methyl]amino]-5-oxo
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino] benzoic acid
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
4-[(Z)-2-ethoxyvinyl]-2-(methylthio)-5-pyrimidinecarbonitrile
4-[(tetraethylbisphosphonomethyl)carbamoyl]butanoic acid

Biological Activity

[Description]:

BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a Ki of 2 nM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RARα

[In Vitro]

BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ-/-, but not activates in RARa-/- cells[1].

[References]

[1]. M Géhin, et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999 Aug;6(8):519-29.

[2]. R Taneja, et al. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12): 6197–6202.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₁NO₄

[ Molecular Weight ]:
351.39600

[ Exact Mass ]:
351.14700

[ PSA ]:
83.47000

[ LogP ]:
3.84800

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport