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Sulfo-EMCS

Names

[ CAS No. ]:
215312-86-0

[ Name ]:
Sulfo-EMCS

[Synonym ]:
sodium 1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate
sulfo-EMCS sodium salt
Sulfo-EMCS
6-Maleimidocaproic Acid Sulfo-N-Succinimidyl Ester
1-[[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]oxy]-2,5-dioxo-3-pyrrolidinesulfonic Acid Sodium Salt

Biological Activity

[Description]:

6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562  

Chemical & Physical Properties

[ Melting Point ]:
158-165 °C

[ Molecular Formula ]:
C14H15N2NaO9S

[ Molecular Weight ]:
410.33

[ Exact Mass ]:
410.04000

[ PSA ]:
166.64000

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds