THP-PEG1-alcohol

Names

[ CAS No. ]:
2162-31-4

[ Name ]:
THP-PEG1-alcohol

[Synonym ]:
2-(Tetrahydro-2H-pyran-2-yloxy)ethanol
Ethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-
2-(oxan-2-yloxy)ethanol

Biological Activity

[Description]:

THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
255.3±30.0 °C at 760 mmHg

[ Melting Point ]:
95ºC 22 mm Hg(lit.)

[ Molecular Formula ]:
C₇H₁₄O₃

[ Molecular Weight ]:
146.184

[ Flash Point ]:
108.2±24.6 °C

[ Exact Mass ]:
146.094299

[ PSA ]:
38.69000

[ LogP ]:
-0.38

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.460

Safety Information

[ Safety Phrases ]:
23-24/25

[ WGK Germany ]:
3

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%