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AR-C 118925XX

Names

[ CAS No. ]:
216657-60-2

[ Name ]:
AR-C 118925XX

[Synonym ]:
AR-C118925XX
2-Furancarboxamide, 5-[[5-(2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-1H-tetrazol-5-yl-
5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d][7]annulen-5-yl)-2-oxo-4-thioxo-3,4-dihydro-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furamide

Biological Activity

[Description]:

AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Research Areas >> Inflammation/Immunology

[Target]

P2Y2 Receptor


[In Vivo]

AR-C118925XX (i.p.) 抑制 Bleomycin 对小鼠真皮厚度的增加[1]。

[References]

[1]. Perera LMB, et al. The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor. J Invest Dermatol. 2019 Apr;139(4):890-899.  

[2]. Dong CR, et al. AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer. Carcinogenesis. 2022 Dec 5:bgac095.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C28H23N7O3S

[ Molecular Weight ]:
537.592

[ Exact Mass ]:
537.158325

[ LogP ]:
4.78

[ Index of Refraction ]:
1.756

Related Compounds