LY-3381916

Names

[ Name ]:
LY-3381916

Biological Activity

[Description]:

LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[Target]

IDO1

[In Vitro]

LY-3381916 (up to 100 µM) shows no obvious agonism of aryl hydrocarbon receptor (AHR)[1].

[References]

[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₅FN₂O₃

[ Molecular Weight ]:
396.45

[ Storage condition ]:
-20°C

LY-3381916

Names

Biological Activity

Chemical & Physical Properties

Related Compounds