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MAK683 hydrochloride

Names

[ CAS No. ]:
2170606-94-5

[ Name ]:
MAK683 hydrochloride

Biological Activity

[Description]:

MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[References]

[1]. Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.

[2]. Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18ClFN6O

[ Molecular Weight ]:
412.85

Related Compounds