PZ-2891

Names

[ Name ]:
PZ-2891

Biological Activity

[Description]:

PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

IC50: 1.3 nM (PANK)[1]

[References]

[1]. Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₃N₅O

[ Molecular Weight ]:
349.43

[ Storage condition ]:
2-8℃

PZ-2891

Names

Biological Activity

Chemical & Physical Properties

Related Compounds