Metapramine

Names

[ Name ]:
Metapramine

[Synonym ]:
Metapramine
Metapramina

Biological Activity

[Description]:

Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1] [2] [3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

NMDA receptor complex channel[4]

[In Vivo]

Metapramine (19560 RP) (0-20 mg/kg; i.p.) shows analgesic effects in mice[5]. Animal Model: Male Swiss albino mice[5] Dosage: 0-20 mg/kg Administration: Intraperitoneal injection Result: Increased jump latency, threshold voltage, reduction in writhes, and tail flick latency in a dose-dependent manner.

[References]

[1]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23.

[2]. H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8.

[3]. J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(2):261-70.

[4]. A Boireau, et al. The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors. Neuropharmacology. 1996;35(12):1703-7.

[5]. Adina Michael-Titus, et al. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 1987 Dec;31(3):391-400. doi: 10.1016/0304-3959(87)90167-9.

Chemical & Physical Properties

[ Density]:
1.12g/cm3

[ Boiling Point ]:
350.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₈N₂

[ Molecular Weight ]:
238.32800

[ Flash Point ]:
140.7ºC

[ Exact Mass ]:
238.14700

[ PSA ]:
15.27000

[ LogP ]:
3.72700

[ Vapour Pressure ]:
4.27E-05mmHg at 25°C

[ Index of Refraction ]:
1.633

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%