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benzetimide

Names

[ CAS No. ]:
21888-98-2

[ Name ]:
benzetimide

[Synonym ]:
Dexbenzetimide
DEXETIMIDE HCL
Dexbenzetimid
Dextrobenzetimide

Biological Activity

[Description]:

Dexetimide ((+)-Benzetimide) is a high-affinity muscarinic receptor antagonist and a potent and persistent anticholinergic agent used to treat neuroleptic-induced parkinsonism[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> mAChR

[References]

[1]. Speck AL, et al. The absolute configuration and crystal structure of the anticholinergic drug dexbenzetimide. Nature. 1971 Aug 20;232(5312):575-6.

[2]. Müller-Gärtner HW, et al. Imaging muscarinic cholinergic receptors in human brain in vivo with Spect, [123I]4-iododexetimide, and [123I]4-iodolevetimide. J Cereb Blood Flow Metab. 1992 Jul;12(4):562-70.

Chemical & Physical Properties

[ Density]:
1.178g/cm3

[ Boiling Point ]:
543.9ºC at 760 mmHg

[ Melting Point ]:
181-183°

[ Molecular Formula ]:
C23H26N2O2

[ Molecular Weight ]:
398.92600

[ Flash Point ]:
282.7ºC

[ Exact Mass ]:
398.17600

[ PSA ]:
49.41000

[ LogP ]:
4.34190

[ Vapour Pressure ]:
6.86E-12mmHg at 25°C

[ Index of Refraction ]:
1.597

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds