Levetimide

Names

[ CAS No. ]:
21888-99-3

[ Name ]:
Levetimide

Biological Activity

[Description]:

Levetimide is a potent and stereoselective inhibitor of [3H](+)pentazocine binding, with a Ki of 2.2 nM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[In Vitro]

Levetimide potently inhibits [3H]DTG binding although without stereoselectivity (Ki value of 103 nM) [1].

[References]

[1]. DeHaven-Hudkins DL, et al. Binding of dexetimide and levetimide to [3H](+)pentazocine- and [3H]1,3-di(2-tolyl)guanidine-defined sigma recognition sites. Life Sci. 1991;49(18):PL135-9.

Chemical & Physical Properties

[ Density]:
1.178g/cm3

[ Boiling Point ]:
543.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₂₆N₂O₂

[ Molecular Weight ]:
362.46500

[ Flash Point ]:
282.7ºC

[ Exact Mass ]:
362.19900

[ PSA ]:
52.90000

[ LogP ]:
3.48700

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA4029500

CHEMICAL NAME :: Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, (-)-

CAS REGISTRY NUMBER :: 21888-99-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H26-N2-O2

MOLECULAR WEIGHT :: 362.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38500 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%