Radequinil

Names

[ CAS No. ]:
219846-31-8

[ Name ]:
Radequinil

[Synonym ]:
UNII-2G222T03EY
2G222T03EY
Radequinil
1,6-Naphthyridin-2(1H)-one, 5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-
5-(3-Methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one
5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine

Biological Activity

[Description]:

Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

Ki: 5.15±0.39 nM (GABA(-) ligand), 6.11±0.26 nM (GABA(+) ligand)[1]

[References]

[1]. Hashimoto T, et al. Pharmacological properties of AC-3933, a novel benzodiazepine receptor partial inverse agonist. Neuroscience. 2014 Jan 3;256:352-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₈H₁₄N₄O₃

[ Molecular Weight ]:
334.33

[ Exact Mass ]:
334.106598

[ LogP ]:
2.54

[ Index of Refraction ]:
1.620