6-bromocoumarin-3-carboxylic acid

Names

[ Name ]:
6-bromocoumarin-3-carboxylic acid

[Synonym ]:
6-bromo-2-oxo-2H-1-benzopyran-3-carboxylic acid
6-Bromochromon-3-carboxylic acid
6-Bromo-2-oxo-2H-chromene-3-carboxylic acid 6-Bromo-3-carboxycoumarin
6-bromo-2-oxo-2Hchromene-3-carboxylic acid
MFCD00047640
6-Bromocoumarin-3-carboxylic acid
6-Bromocoumarin-3-carboxylicAcid

Biological Activity

[Description]:

UBP608 is a potent N-Methyl-D-aspartate receptors (NMDARs) negative allosteric modulator. UBP608 has the potential for the research of neurological disorders[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

NMDA Receptor

[In Vitro]

UBP608 (100 µM) 显示出抑制活性，对 GluN1/GluN2A、GluN1/GluN2B、GluN1/GluN2C、GluN1/GluN2D 的抑制率分别为 89.3%、63.5%、56.1%、23.6%[1]。

[References]

[1]. Irvine MW, et al. Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int. 2012 Sep;61(4):593-600.

Chemical & Physical Properties

[ Density]:
1.874g/cm3

[ Boiling Point ]:
439ºC at 760mmHg

[ Melting Point ]:
195-198 °C(lit.)

[ Molecular Formula ]:
C₁₀H₅BrO₄

[ Molecular Weight ]:
269.04800

[ Flash Point ]:
219.3ºC

[ Exact Mass ]:
267.93700

[ PSA ]:
67.51000

[ LogP ]:
2.25370

[ Vapour Pressure ]:
1.76E-08mmHg at 25°C

[ Storage condition ]:
room temp

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%