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Prolyl Hydroxylase inhibitor 1

Names

[ CAS No. ]:
2205125-60-4

[ Name ]:
Prolyl Hydroxylase inhibitor 1

Biological Activity

[Description]:

Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM[1]. Antianemia agent[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[Target]

IC50: 62.23±2.33nM (HIF-PHD)[1]


[References]

[1]. Wu Y, et al. Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia. J Med Chem. 2018 Jun 28;61(12):5332-5349.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H18ClN5O4

[ Molecular Weight ]:
415.83

Related Compounds