FIM-1

Names

[ CAS No. ]:
220518-50-3

[ Name ]:
FIM-1

[Synonym ]:
3',6'-Dihydroxy-N-(3-{3-[4-(1-methyl-1H-indol-2-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxamide
Fim-1
N-[3-(3-[2,5-DIHYDRO-4-(1-METHYL-1H-INDOL-3-YL)-2,5-DIOXO-1H-PYRROL-3-YL]-1H-INDOL-1-YL)PROPYL]-3',6'-DIHYDROXY-3-OXOSPIRO[ISOBENZOFURAN-1[3H],9'-[9H]XANTHENE]-5-CARBOXAMIDE
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxamide, N-[3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-2-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl]-3',6'-dihydroxy-3-oxo-
MFCD03453075

Biological Activity

[Description]:

FIM-1 is a fluorescent PKC (protein kinase C) probe that can be used for mitochondrial staining. FIM-1 inhibits PKC and acts as ATP-competitive catalytic site inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Others

Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Chen CS, et al. New fluorescent probes for protein kinase C. Synthesis, characterization, and application. J Biol Chem. 1993 Jul 25;268(21):15812-22.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₄₅H₃₂N₄O₈

[ Molecular Weight ]:
756.758

[ Exact Mass ]:
756.221985

[ LogP ]:
5.84

[ Index of Refraction ]:
1.761

[ Storage condition ]:
Store at -20° C

[ Water Solubility ]:
Soluble in DMSO or DMF.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems.

BMC Bioinformatics 7 , 483, (2006)

We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-modality of many of these problems...