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CP-226269

Names

[ CAS No. ]:
220941-93-5

[ Name ]:
CP-226269

[Synonym ]:
HMS3263O08
5-fluoro-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1H-indole
5-fluoro-2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-indole
5-Fluoro-2-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-1H-indole

Biological Activity

[Description]:

CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32.0 nM. CP 226269 can be used in the research of schizophrenia and other related diseases[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[References]

[1]. Robert B Moreland, et al. Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5). Biochem Pharmacol. 2004 Aug 15;68(4):761-72.   

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19FN4

[ Molecular Weight ]:
310.37

[ Exact Mass ]:
310.15900

[ PSA ]:
35.16000

[ LogP ]:
3.02710

MSDS

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Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds