Norswertianin

Names

[ Name ]:
Norswertianin

[Synonym ]:
1,2,6,8-tetrahydroxyxanthen-9-one
1,3,7,8-Tetrahydroxyxanthone
1,2,6,8-tetrahydroxy-xanthen-9-one
1,2,6,8-Tetrahydroxyxanthone
Norswertianin
Xanthen-9-one,1,2,6,8-tetrahydroxy
1,2,6,8-Tetrahydroxy-9H-xanthen-9-one
1,2,6,8-Tetrahydroxy-xanthen-9-on
1,3,7,8-Tetrahydroxyxanthon
norswetianin

Biological Activity

[Description]:

Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Norswertianin (12.5-50 µM; 48 hours) stimulats expression of GFAP and β-tubulin in U251 cells[1]. Norswertianin (40 µM; 48 hours) causes the appearance of elongated processes in U251 cells, associated with G2/M cell cycle arrest[1]. Norswertianin (40 µM; 48 hours) exhibits an increase in intracellular acidification and LC3 conversion[1].

[References]

[1]. Gordana Tovilovic-Kovacevic, et al. Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line. Phytomedicine

Chemical & Physical Properties

[ Density]:
1.766g/cm3

[ Boiling Point ]:
601.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₈O₆

[ Molecular Weight ]:
260.19900

[ Flash Point ]:
240.4ºC

[ Exact Mass ]:
260.03200

[ PSA ]:
111.13000

[ LogP ]:
1.76860

[ Vapour Pressure ]:
4.49E-15mmHg at 25°C

[ Index of Refraction ]:
1.801

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%