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MI-389

Names

[ CAS No. ]:
2222635-92-7

[ Name ]:
MI-389

Biological Activity

[Description]:

MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC

[Target]

Cereblon


[References]

[1]. Ishoey M, et al. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders. ACS Chem Biol. 2018;13(3):553-560.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H35FN6O6

[ Molecular Weight ]:
654.69

Related Compounds