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EGFR-IN-5

Names

[ CAS No. ]:
2225887-26-1

[ Name ]:
EGFR-IN-5

[Synonym ]:
MFCD31813637

Biological Activity

[Description]:

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:10.4 nM (IC50)

EGFRL858R:1.1 nM (IC50)

EGFRL858R/T790M:34 nM (IC50)

EGFRL858R/T790M/C797S:7.2 nM (IC50)


[References]

[1]. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H38FN9O

[ Molecular Weight ]:
571.69

Related Compounds