ATG7-IN-3

Names

[ CAS No. ]:
2226229-76-9

[ Name ]:
ATG7-IN-3

Biological Activity

[Description]:

ATG7-IN-3 (compound 18) is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy

[Target]

IC50: 0.048 ± 0.022 μM (ATG7), 0.280 ± 0.051 μM (Thioester), 0.938 ± 0.231 μM (LC3B)[1]


[References]

[1]. Huang SC, et al. Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115681.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H16N6O5S2

[ Molecular Weight ]:
376.41

Related Compounds