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Dynapyrazole-A

Names

[ CAS No. ]:
2226517-75-3

[ Name ]:
Dynapyrazole-A

[Synonym ]:
2-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxopyrazolo[1,5-a]quinazoline-3-carbonitrile
2-[1-(4-Chlorophenyl)cyclopropyl]-7-iodo-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carbonitrile
2-[1-(4-Chloro-phenyl)-cyclopropyl]-7-iodo-5-oxo-4,5-dihydro-pyrazolo[1,5-a]quinazoline-3-carbonitrile
Pyrazolo[1,5-a]quinazoline-3-carbonitrile, 2-[1-(4-chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxo-
Dynapyrazole-A

Biological Activity

[Description]:

Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cytoskeleton >> Dynamin

[In Vitro]

Dynapyrazole A (1- 3 μg/mL, 14 h) 在感染了 RVA-NMTL 病毒的 MA-104 细胞中，可以以剂量依赖的方式降低病毒滴度，EC 50 值为 0.73 μg/mL[1]。

[References]

[1]. Zhaoyang Jing, et al. Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain. J Virol. 2021 Oct 13;95(21):e0124621.   

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
551.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H12ClIN4O

[ Molecular Weight ]:
486.7

[ Flash Point ]:
287.2±30.1 °C

[ Exact Mass ]:
485.974426

[ LogP ]:
5.45

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.821

Related Compounds