TL 13-22

Names

[ Name ]:
TL 13-22

Biological Activity

[Description]:

TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[Target]

IC50: 0.54 nM (ALK)[1]

[In Vitro]

TL13-22 prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 11.3 nM, 5.74 nM, 18.4 nM, and 65.9 nM, respectively[1].

[References]

[1]. Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₅₅ClN₁₀O₉S

[ Molecular Weight ]:
947.50

TL 13-22

Names

Biological Activity

Chemical & Physical Properties

Related Compounds