TL 13-110

Names

[ Name ]:
TL 13-110

Biological Activity

[Description]:

TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[Target]

IC50: 0.34 nM (ALK); 81 μM (Cereblon)[1]

[In Vitro]

TL13-110 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 9080 nM, 23.1 nM, 21.2 nM, and 480 nM, respectively.

[References]

[1]. Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₉H₆₂ClN₉O₉S

[ Molecular Weight ]:
988.59

TL 13-110

Names

Biological Activity

Chemical & Physical Properties

Related Compounds