PKCiota-IN-1

Names

[ CAS No. ]:
2230052-97-6

[ Name ]:
PKCiota-IN-1

Biological Activity

[Description]:

PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKCι:2.7 nM (IC50)

PKCα:45 nM (IC50)

PKCε:450 nM (IC50)


[References]

[1]. Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H22FN5O

[ Molecular Weight ]:
427.47

Related Compounds