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KDM4-IN-4

Names

[ CAS No. ]:
2230475-63-3

[ Name ]:
KDM4-IN-4

Biological Activity

[Description]:

KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC50 value of 105 μM. KDM4-IN-4 can be used for researching anticancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Demethylase

[Target]

KDM4A-Tudor domain:80 μM (Ki)


[References]

[1]. Wu Q, Young B, Wang Y, Davidoff AM, Rankovic Z, Yang J. Recent Advances with KDM4 Inhibitors and Potential Applications. J Med Chem. 2022 Jul 15.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H23NO

[ Molecular Weight ]:
245.36

Related Compounds