KRAS inhibitor-12

Names

[ CAS No. ]:
2230874-00-5

[ Name ]:
KRAS inhibitor-12

Biological Activity

[Description]:

KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:0.537 μM (IC50)


[References]

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Chemical & Physical Properties

[ Molecular Formula ]:
C19H16Cl2FN5OS

[ Molecular Weight ]:
452.33

Related Compounds