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MT-802

Names

[ CAS No. ]:
2231744-29-7

[ Name ]:
MT-802

Biological Activity

[Description]:

MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Signaling Pathways >> PROTAC >> PROTAC

[Target]

DC50: 1 nM (BTK)[1].


[In Vitro]

MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].

[References]

[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.

Chemical & Physical Properties

[ Molecular Formula ]:
C41H41N9O8

[ Molecular Weight ]:
787.82

[ Storage condition ]:
-20°C

Related Compounds