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Keap1-Nrf2-IN-1

Names

[ CAS No. ]:
2232112-72-8

[ Name ]:
Keap1-Nrf2-IN-1

Biological Activity

[Description]:

Keap1–Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1–Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

IC50: 43 nM (Keap1 protein)[1]


[References]

[1]. Lu MC, et al. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem. 2019 Jul 25;62(14):6796-6813.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24N2O7S

[ Molecular Weight ]:
484.52

Related Compounds