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Virgaureagenin G

Names

[ CAS No. ]:
22338-71-2

[ Name ]:
Virgaureagenin G

[Synonym ]:
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic
Polygalacicacid
Virgaureagenin G
(2β,3β,5ξ,16α,18α)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Vigaureagenin G
Olean-12-en-28-oic acid, 2,3,16,23-tetrahydroxy-, (2β,3β,5ξ,16α,18α)-
Polygalac Saeure

Biological Activity

[Description]:

Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[In Vitro]

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1]. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1]. RT-PCR[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 24 hours Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western Blot Analysis[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 6 hours Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

[References]

[1]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252.

[2]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23(2):149-55.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
638.1±55.0 °C at 760 mmHg

[ Melting Point ]:
315-318ºC

[ Molecular Formula ]:
C30H48O6

[ Molecular Weight ]:
504.698

[ Flash Point ]:
353.7±28.0 °C

[ Exact Mass ]:
504.345093

[ PSA ]:
118.22000

[ LogP ]:
5.03

[ Vapour Pressure ]:
0.0±4.3 mmHg at 25°C

[ Index of Refraction ]:
1.593

Safety Information

[ HS Code ]:
29163990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds