PI3Ka-IN-5

Names

[ Name ]:
PI3Ka-IN-5

Biological Activity

[Description]:

PI3Ka-IN-5 (compound 6 ab) is a potent PI3Kα/mTOR inhibitor, with an IC50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα:0.7 nM (IC50)

mTOR:3.3 nM (IC50)

[References]

[1]. Wu CF, et, al. Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer. Eur J Med Chem. 2022 Feb 5;229:114055.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₅N₉O₅

[ Molecular Weight ]:
601.66

PI3Ka-IN-5

Names

Biological Activity

Chemical & Physical Properties

Related Compounds