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Oleoyl-D-lysine

Names

[ CAS No. ]:
2240164-55-8

[ Name ]:
Oleoyl-D-lysine

Biological Activity

[Description]:

Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

Glycine Transporter-2 (GlyT2)[1]


[In Vivo]

Oleoyl-D-lysine effectively reverses neuropathic pain in a mouse model of chronic neuropathic (chronic constriction injury) pain, reaching a peak analgesic dose of 30 mg/kg without causing respiratory depression; resultig mild side effects at 100 mg/kg without causing convulsions[1].

[References]

[1]. Wilson BS, et al. Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice. J Pharmacol Exp Ther. 2022 Sep;382(3):246-255.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H46N2O3

[ Molecular Weight ]:
410.63

Related Compounds